Antiplasmodial and cytotoxic activity of khellactone derivatives from Angelica purpuraefolia chung
Identifieur interne : 001744 ( Main/Exploration ); précédent : 001743; suivant : 001745Antiplasmodial and cytotoxic activity of khellactone derivatives from Angelica purpuraefolia chung
Auteurs : Ill-Min Chung [Corée du Sud] ; Bimal Kumar Ghimire [Corée du Sud] ; Eun-Young Kang [Corée du Sud] ; Hyung-In Moon [Corée du Sud]Source :
- Phytotherapy Research [ 0951-418X ] ; 2010-03.
English descriptors
- Teeft :
- Agelica purpuraefolia, Angelica, Angelica purpuraefolia, Antimalarial activity, Antiplasmodial, Antiplasmodial activity, Artemisinin, Assay, Cancer cell line cells, Chloroquine, Chloroquine diphosphate, Control culture, Copyright, Cytotoxic activity, Cytotoxicity, Different concentrations, Dongguk university, Falciparum, Genus angelica, Inhibitory concentrations, Isolation compounds, John wiley sons, Khellactone, Korean medicine, Major compounds, Natural khellactone, Parasite, Parasitemia decrease, Phytother, Plasmodium, Plasmodium falciparum, Purpuraefolia, Rhizome, Rhizomes parts, Seoul, Spectral data, Standard compounds, Wonkwang university sanbon.
Abstract
The methanolic extract of the rhizomes parts of Agelica purpuraefolia was investigated for its activity against chloroquine‐sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method. Two natural khellactone, (+)‐4′‐Decanoyl‐cis‐khellactone (1) and (+)‐3′‐Decanoyl‐cis‐khellactone (2) were isolated from the rhizomes parts of A. purpuraefolia. Two compounds were evaluated for in vitro antiplasmodial activities as well as their cytotoxic potential on SK‐OV‐3 cancer cell line cells. Compounds 1, 2 showed notable growth inhibitory activity against chloroquine‐sensitive strains of Plasmodium falciparum with IC50 values from 1.5 and 2.4 μM. This compound showed no significant cytotoxicity (IC50 > 100 μM) evaluated using SK‐OV‐3 cancer cell line cells. This is the first report on the antiplasmodial activity of the compounds from A. purpuraefolia. Copyright © 2009 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/ptr.3056
Affiliations:
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Two natural khellactone, (+)‐4′‐Decanoyl‐cis‐khellactone (1) and (+)‐3′‐Decanoyl‐cis‐khellactone (2) were isolated from the rhizomes parts of A. purpuraefolia. Two compounds were evaluated for in vitro antiplasmodial activities as well as their cytotoxic potential on SK‐OV‐3 cancer cell line cells. Compounds 1, 2 showed notable growth inhibitory activity against chloroquine‐sensitive strains of Plasmodium falciparum with IC50 values from 1.5 and 2.4 μM. This compound showed no significant cytotoxicity (IC50 > 100 μM) evaluated using SK‐OV‐3 cancer cell line cells. This is the first report on the antiplasmodial activity of the compounds from A. purpuraefolia. 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